What this entity is
Canonical name: Glyoxylate shunt. 1
Known aliases: No aliases are reported in this document. 1
Stable external identifier: No stable external identifier is reported in this document. 1
The glyoxylate shunt is a metabolic pathway identified here through acetate-associated deletion phenotypes. 1
Evidence across studies
Acetate condition-specific genes included fadB, malate synthase G, and citB, which the report associates with fatty acid β-oxidation and the glyoxylate shunt. 1
These findings place the glyoxylate shunt within the acetate-specific metabolic architecture detected in the Acinetobacter baylyi ADP1 deletion collection. 1
The acetate result contributes to the broader finding that 625 genes, or 31% of the complete 2,034-gene matrix, had a condition-specificity score of at least 1.0. 1
The Harvard Forest warming study refines this acetate-associated evidence by detecting increased RNA signals for the glyoxylate-cycle genes aceA/icl (K01637) and aceB/glcB (K01638) in heated mineral soil: log2 fold changes were +0.460 and +0.268, respectively, with p=0.037 for each. 2 These gene-level signals extend the pathway’s observed environmental context beyond ADP1 deletion phenotypes, but they were not established as FDR-significant across 14K KOs. 2
Related pages
The acetate-associated pathway requirement feeds into condition-specific-fitness, which synthesizes how gene importance depends on the tested carbon source. 1
It also relates to gene-essentiality, because the deletion results identify pathway genes whose growth importance is condition-dependent rather than universally essential. 1
The warming evidence connects the pathway to multi-omics-integration through a transcript-pool response, while the complete analysis is summarized in Harvard Forest Long-Term Warming — DNA vs RNA Functional Response. 2
The source analysis is summarized in ADP1 Deletion Collection Phenotype Analysis. 1