Identity
Canonical name: Urea. 1
Known aliases: No aliases were reported in the source document. 1
Stable external identifier: No stable external identifier was reported in the source document. 1
Key Facts
Urea was one of 8 carbon sources used to measure mutant growth fitness in the Acinetobacter baylyi ADP1 database. 1
The deletion-phenotype analysis refines urea’s characterization as a demanding condition: it had the lowest mean growth ratio, 0.41, with 97.9% of genes showing severe defects at growth ratio < 0.5 and 95–100% defective at ratio < 0.8. 2 The respiratory-chain analysis supports and refines this characterization, reporting that urea was generally demanding and required everything in the reported respiratory-chain profile. 3
Urea fitness had a pairwise correlation of r = 0.11 with quinate fitness. 1
Urea fitness was weakly correlated with all other tested conditions, with correlations ranging from r = 0.12-0.28. 1
The report interprets the weak correlations as suggesting that urea catabolism involves a largely independent set of genes; this remains a dataset-specific hypothesis rather than an established cross-species finding. 1 The new analysis supports and refines this interpretation: principal component analysis (PCA), which summarizes correlated variation into orthogonal components, isolated urea from carbon metabolism, with a loading of +0.75 on PC2. 2
Urea-specific genes included ureA, ureB, ureC, ureD, ureE, ureF, and ureG, representing the urease complex. 2
These measurements are part of the ADP1-centered resource described in Acinetobacter baylyi ADP1 Data Explorer, which contributes mutant growth fitness data unavailable for ADP1 in the Fitness Browser. 1
The deletion analysis is described in ADP1 Deletion Collection Phenotype Analysis. 2 The respiratory-chain interpretation is described in Condition-Specific Respiratory Chain Wiring in ADP1. 3
Related Pages
- condition-specific-fitness — condition-specific mutant-growth fitness patterns involving urea. 1
- gene-essentiality — urea’s demanding-condition phenotype and urea-specific gene requirements refine condition-dependent essentiality. 2
- urease complex — urea-specific genes include the urease-complex components. 2
- acinetobacter-baylyi-adp1 — organism used for the urea fitness measurements. 1