Identity
Glucose is the canonical name used for this carbon-source condition in the ADP1 deletion phenotype analysis. 1
- Known aliases: None specified in the source. 1
- Stable external identifier: Not reported in the source. 1
Evidence from ADP1 deletion phenotypes
Glucose belongs to the robust condition tier, together with glucarate and quinate, in the eight-carbon-source deletion matrix. 1
Across the robust tier, mean growth ratios range from 1.25 to 1.36 and 0.5–2.4% of genes show growth defects. 1
Growth ratios are mutant/wild-type values, with values below 1.0 indicating growth defects and values above 1.0 indicating no defect or a slight growth advantage from experimental normalization. 1
Glucose selects condition-specific genes associated with the entner-doudoroff-pathway, including eda, gntT, gluconokinase, and glucose dehydrogenase (PQQ). 1
PQQ biosynthesis genes are condition-specific for both glucose and quinate, consistent with PQQ-dependent dehydrogenases catalyzing the first step of both pathways. 1
Respiratory-chain wiring
The respiratory-chain analysis refines glucose’s condition-specific profile: no specifically required respiratory component was identified, and all listed components showed full redundancy. 2 Complex I had a growth ratio of 1.44 on glucose, compared with 0.37 on quinate and 0.49 on acetate, supporting a condition-specific rather than uniformly essential respiratory requirement. 2
The report proposes that glucose distributes NADH production across Entner–Doudoroff pathway steps and the TCA cycle, rather than producing the concentrated TCA-cycle NADH burst proposed for quinate; this is a theoretical stoichiometric interpretation, not a measured flux distribution. 2 Glucose produces 9 total NADH, or 1.50 NADH per carbon. 2 These findings support condition-specific-fitness by linking glucose pathway use with a distinct respiratory configuration. 2
The glucose findings contribute to condition-specific-fitness by showing that carbon-source choice identifies pathway-specific fitness requirements. 1
Related pages
- ADP1 Deletion Collection Phenotype Analysis — source report for the ADP1 deletion phenotype analysis.
- Condition-Specific Respiratory Chain Wiring in ADP1 — source report on carbon-dependent respiratory-chain configuration in ADP1.
- entner-doudoroff-pathway — pathway associated with glucose-specific genes.
- pqq-biosynthesis — biosynthetic process linked to glucose-dependent dehydrogenase activity.
- condition-specific-fitness — cross-project synthesis of condition-dependent growth effects.