Identity
Canonical name: Valine. 1
Known aliases: No aliases were reported in the source document. 1
Stable external identifier: No stable external identifier was reported in the source document. 1
Evidence from fw300_metabolic_consistency
Valine emerged in the web-of-microbes exometabolome of Pseudomonas FW300-N2E3. 1
Valine had a complete pathway prediction from gapmind and supported growth involving 160 significant gene effects in kescience-fitnessbrowser. 1
Valine was utilized by 1/1 matched bacdive strain, corresponding to 100% utilization in the available species-level data. 1
Valine was one of three metabolites—along with malate and arginine—with four-way concordance across WoM production or emergence, Fitness Browser growth data, BacDive utilization, and GapMind pathway prediction. 1
The valine result therefore supports the cross-database integration described in multi-omics-integration and the pathway-completeness evidence discussed in metabolic-model-gapfilling. 1
The 160 significant gene effects associated with valine contribute to the report’s broader interpretation of condition-specific fitness landscapes, while the source cautions that broadly pleiotropic amino-acid-biosynthesis genes can reflect housekeeping requirements rather than substrate-specific catabolism. 1
Pathway capability and dependency
The new pathway-level analysis refines the prior complete-pathway result: across its species set, valine biosynthesis had all-gene completeness of 0.614, core-only completeness of 0.468, and an accessory-dependent gap of 0.146. 2 This supports the interpretation that valine biosynthetic capacity can partly depend on genes outside the universally conserved core, while the analysis does not demonstrate valine exchange between organisms. 2
The analysis also distinguished genomic pathway capability from experimentally observed dependency, so a complete valine pathway need not imply fitness importance under standard conditions. 2
Source
- Metabolic Consistency of Pseudomonas FW300-N2E3 Across Four KBase Data Lakehouse Databases — cross-database analysis of FW300-N2E3 metabolite production, growth capability, species-level utilization, and pathway completeness.
- Metabolic Capability vs Dependency — comparison of GapMind pathway completeness, accessory-gene contribution, and fitness-based dependency.