What this entity is
Canonical name: manganese. 1
Known aliases: None specified in the source. 1
Stable external identifier: None specified in the source. 1
Key facts
Manganese was classified among the essential metals analyzed in the Pan-Bacterial Metal Fitness Atlas. 1
Manganese showed the strongest core-genome enrichment among the 14 metals examined: all 30 manganese-important genes were classified as core, giving a core fraction of 1.000 and a core-fraction delta of +0.198. 1
The manganese enrichment had an odds ratio of infinity (OR=inf) and was statistically significant (p=2.0e-03). 1
The manganese result contributed to the finding that essential-metal tolerance genes had a mean core-fraction delta of +0.148, compared with +0.081 for toxic metals; this difference was significant by one-sided Mann-Whitney U testing (U=39, p=0.015). 1
The newer metal-specificity analysis found that 20 of 33 manganese-associated gene records (60.6%) were metal-specific, meaning they showed significant fitness defects under metal stress but a <5% sick rate across non-metal experiments. This refines the atlas result: manganese-important genes can be strongly core-enriched while a substantial fraction of the measured determinants show comparatively specific metal-stress defects. 2
The manganese result supports the atlas’s two-tier model in metal-cross-resistance, in which broadly required core cellular functions are distinguished from accessory specialized metal-resistance mechanisms. The metal-specificity result further supports this distinction by separating metal-specific determinants from genes broadly sick across conditions; details are reported in Metal-Specific vs General Stress Genes. 2